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One‐Dimensional Fe 2 P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics
Author(s) -
Liu Yang,
Zhen Wenyao,
Wang Yinghui,
Liu Jianhua,
Jin Longhai,
Zhang Tianqi,
Zhang Songtao,
Zhao Ying,
Song Shuyan,
Li Chengyu,
Zhu Junjie,
Yang Yang,
Zhang Hongjie
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201813702
Subject(s) - photothermal therapy , photoacoustic imaging in biomedicine , nanorod , biocompatible material , phosphide , materials science , chemistry , fenton reaction , magnetic resonance imaging , nanotechnology , nuclear magnetic resonance , biomedical engineering , metal , catalysis , optics , organic chemistry , medicine , physics , radiology
The stringent reaction conditions for an effective Fenton reaction (pH range of 3–4) hinders its application in cancer therapy. Therefore, how to improve the efficiency of the Fenton reaction in a tumor site has been the main obstacle in chemodynamic therapy (CDT). Herein, we report biocompatible one‐dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)‐ and photothermal (PT)‐enhanced Fenton properties and excellent photothermal conversion efficiency (56.6 %) in the NIR II window, showing synergistic therapeutic properties. Additionally, the high photothermal conversion efficiency and excellent traverse relaxivity (277.79 m m −1 s −1 ) of the FP NRs means they are excellent photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agents. This is the first report on exploiting the response of metallic phosphides to NIR II laser (1064 nm) and ultrasound to improve the CDT effect with a high therapeutic effect and PA/MR imaging.