Premium
Enantioselective Aluminum‐Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold
Author(s) -
Loup Joachim,
Müller Valentin,
Ghorai Debasish,
Ackermann Lutz
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201813191
Subject(s) - enantioselective synthesis , nickel , alkene , reagent , chemistry , catalysis , selectivity , stereochemistry , combinatorial chemistry , organic chemistry
Highly enantioselective nickel‐catalyzed alkene endo ‐hydroarylations were accomplished with full selectivity by organometallic C−H activation. The asymmetric assembly of chiral six‐membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom