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Peptide‐Coated Platinum Nanoparticles with Selective Toxicity against Liver Cancer Cells
Author(s) -
Shoshan Michal S.,
Vonderach Thomas,
Hattendorf Bodo,
Wennemers Helma
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201813149
Subject(s) - peptide , cytotoxicity , toxicity , chemistry , cancer cell , cisplatin , liver cancer , platinum nanoparticles , biochemistry , platinum , biophysics , cancer research , cancer , in vitro , biology , organic chemistry , catalysis , chemotherapy , hepatocellular carcinoma , genetics
Abstract Peptide‐stabilized platinum nanoparticles (PtNPs) were developed that have significantly greater toxicity against hepatic cancer cells (HepG2) than against other cancer cells and non‐cancerous liver cells. The peptide H‐Lys‐Pro‐Gly‐ d Lys‐NH 2 was identified by a combinatorial screening and further optimized to enable the formation of water‐soluble, monodisperse PtNPs with average diameters of 2.5 nm that are stable for years. In comparison to cisplatin, the peptide‐coated PtNPs are not only more toxic against hepatic cancer cells but have a significantly higher tumor cell selectivity. Cell viability and uptake studies revealed that high cellular uptake and an oxidative environment are key for the selective cytotoxicity of the peptide‐coated PtNPs.