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Tumor‐Microenvironment‐Induced Degradation of Ultrathin Gadolinium Oxide Nanoscrolls for Magnetic‐Resonance‐Imaging‐Monitored, Activatable Cancer Chemotherapy
Author(s) -
Wu Miaomiao,
Xue Yumeng,
Li Na,
Zhao Hongyang,
Lei Bo,
Wang Min,
Wang Jianwei,
Luo Meng,
Zhang Chao,
Du Yaping,
Yan Chunhua
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201812972
Subject(s) - tumor microenvironment , in vivo , magnetic resonance imaging , gadolinium , in vitro , chemistry , materials science , cancer research , nanotechnology , nanomaterials , cancer , tumor cells , biochemistry , medicine , microbiology and biotechnology , organic chemistry , radiology , biology
The development of biodegradable inorganic nanoparticles with a tumor microenvironment‐activated therapeutic mode of action is urgently needed for precision cancer medicine. Herein, the synthesis of ultrathin lanthanide nanoscrolls (Gd 2 O 3 NSs) is reported, which biodegrade upon encountering the tumor microenvironment. The Gd 2 O 3 NSs showed highly controlled magnetic properties, which enabled their high‐resolution magnetic resonance imaging (MRI). Importantly, Gd 2 O 3 NSs degrade in a pH‐responsive manner and selectively penetrate tumor tissue, enabling the targeted release of anti‐cancer drugs. Gd 2 O 3 NSs can be efficiently loaded with an anti‐cancer drug (DOX, 80 %) and significantly inhibit tumor growth with negligible cellular and tissue toxicity both in vitro and in vivo. This study may provide a novel strategy to design tumor microenvironment‐responsive inorganic nanomaterials for biocompatible bioimaging and biodegradation‐enhanced cancer therapy.