Enantioselective C(sp 3 )–H Amidation of Thioamides Catalyzed by a Cobalt III /Chiral Carboxylic Acid Hybrid System | Zendy

Fukagawa Seiya | Zendy; Kato Yoshimi | Zendy; Tanaka Ryo | Zendy; Kojima Masahiro | Zendy; Yoshino Tatsuhiko | Zendy; Matsunaga Shigeki | Zendy

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Enantioselective C(sp 3 )–H Amidation of Thioamides Catalyzed by a Cobalt III /Chiral Carboxylic Acid Hybrid System

Author(s) -

Fukagawa Seiya,

Kato Yoshimi,

Tanaka Ryo,

Kojima Masahiro,

Yoshino Tatsuhiko,

Matsunaga Shigeki

Publication year - 2019

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201812215

Subject(s) - enantioselective synthesis , stereocenter , catalysis , chemistry , cobalt , carboxylic acid , chirality (physics) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , chiral symmetry , physics , quantum mechanics , quark , nambu–jona lasinio model

Recent advances in Cp x M III catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp 2 )−H functionalization reactions, but enantioselective C(sp 3 )−H functionalization is still largely unexplored. We describe an asymmetric C(sp 3 )−H amidation of thioamides using an achiral Co III /chiral carboxylic acid hybrid catalytic system, which provides easy and straightforward access to chiral β‐amino thiocarbonyl and β‐amino carbonyl building blocks with a quaternary carbon stereocenter.

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