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Direct Evidence for the Polymeric Nature of Polydopamine
Author(s) -
Delparastan Peyman,
Malollari Katerina G.,
Lee Haeshin,
Messersmith Phillip B.
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201811763
Subject(s) - polymer , surface modification , covalent bond , force spectroscopy , non covalent interactions , polymer science , adhesive , materials science , nanotechnology , molecule , characterization (materials science) , chemical engineering , polymer chemistry , chemistry , atomic force microscopy , hydrogen bond , organic chemistry , composite material , layer (electronics) , engineering
Inspired by the adhesive proteins of mussels, polydopamine (pDA) has emerged as one of the most widely employed materials for surface functionalization. Despite numerous attempts at characterization, little consensus has emerged regarding whether pDA is a covalent polymer or a noncovalent aggregate of low molecular weight species. Here, we employed single‐molecule force spectroscopy (SMFS) to characterize pDA films. Retraction of a pDA‐coated cantilever from an oxide surface shows the characteristic features of a polymer with contour lengths of up to 200 nm. pDA polymers are generally weakly bound to the surface through much of their contour length, with occasional “sticky” points. Our findings represent the first direct evidence for the polymeric nature of pDA and provide a foundation upon which to better understand and tailor its physicochemical properties.