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C−I‐Selective Cross‐Coupling Enabled by a Cationic Palladium Trimer
Author(s) -
Diehl Claudia J.,
Scattolin Thomas,
Englert Ulli,
Schoenebeck Franziska
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201811380
Subject(s) - trimer , reactivity (psychology) , bimetallic strip , palladium , chemistry , catalysis , cationic polymerization , transition metal , alkylation , coupling reaction , combinatorial chemistry , computational chemistry , photochemistry , polymer chemistry , dimer , organic chemistry , medicine , alternative medicine , pathology
Abstract While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air‐stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C−I over C−Br bonds in C−C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd 0 and Pd I ‐Pd I catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible.