Attrition‐Enhanced Deracemization of the Antimalaria Drug Mefloquine | Zendy

Engwerda Anthonius H. J. | Zendy; Maassen Rick | Zendy; Tinnemans Paul | Zendy; Meekes Hugo | Zendy; Rutjes Floris P. J. T. | Zendy; Vlieg Elias | Zendy

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Attrition‐Enhanced Deracemization of the Antimalaria Drug Mefloquine

Author(s) -

Engwerda Anthonius H. J.,

Maassen Rick,

Tinnemans Paul,

Meekes Hugo,

Rutjes Floris P. J. T.,

Vlieg Elias

Publication year - 2019

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201811289

Subject(s) - mefloquine , enantiomer , malaria , drug , pharmacology , racemic mixture , chirality (physics) , chemistry , stereochemistry , plasmodium falciparum , combinatorial chemistry , medicine , immunology , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark

Mefloquine is an important drug for prevention and treatment of malaria. It is commercially available as a racemic mixture, wherein only one enantiomer is active against malaria, while the other one causes severe psychotropic effects. By converting the drug into a compound that crystallizes as a racemizable racemic conglomerate, the deracemization of mefloquine into the desired enantiomer was achieved.

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