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Amidyl Radical Directed Remote Allylation of Unactivated sp 3 C−H Bonds by Organic Photoredox Catalysis
Author(s) -
Wu Kui,
Wang Lushun,
ColónRodríguez Sonivette,
Flechsig GerdUwe,
Wang Ting
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201811004
Subject(s) - chemistry , amide , catalysis , photocatalysis , sulfone , photochemistry , organic chemistry , medicinal chemistry , combinatorial chemistry
The development of visible‐light‐mediated allylation of unactivated sp 3 C−H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre‐functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C−H allylation products in good yields. A variety of electron deficient allyl sulfone systems could be used as δ‐carbon radical acceptor.