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Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects
Author(s) -
Zhou Wenhua,
Pan Ting,
Cui Haodong,
Zhao Zhen,
Chu Paul K.,
Yu XueFeng
Publication year - 2019
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810878
Subject(s) - cancer cell , intracellular , doxorubicin , chemistry , apoptosis , black phosphorus , oxidative stress , nanomedicine , in vivo , cancer , programmed cell death , cancer research , pharmacology , biochemistry , nanotechnology , chemotherapy , materials science , biology , nanoparticle , medicine , microbiology and biotechnology , optoelectronics
Black phosphorus nanosheets (BPs) are demonstrated to be highly bioactive anti‐cancer agents because of their inherent and selective chemotherapeutic effects. Fast intracellular biodegradation of BPs and acute elevation of phosphate anions were observed from different types of cancer cells due to the stronger intracellular oxidative stress and accelerated energy metabolism, but normal cells are not affected. Selective biodegradation of BPs induced G2/M phase arrest and subsequent apoptosis‐ and autophagy‐mediated cell death in cancer cells but not normal cells. The selectivity was superior to that of the traditional chemotherapeutic agent, doxorubicin (DOX). In vivo assessment confirmed the efficiency of BPs in suppressing tumor growth. This study provides insights into nanostructured bioactive anti‐cancer agents and reveals a new direction for nanomedicine research.