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Metal‐Free Radical Borylation of Alkyl and Aryl Iodides
Author(s) -
Cheng Ying,
MückLichtenfeld Christian,
Studer Armido
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810782
Subject(s) - borylation , chemistry , aryl , alkyl , aryl radical , boron , functional group , density functional theory , photochemistry , medicinal chemistry , organic chemistry , computational chemistry , polymer
A metal‐free radical borylation of alkyl and aryl iodides with bis(catecholato)diboron (B 2 cat 2 ) as the boron source under mild conditions is introduced. The borylation reaction is operationally easy to conduct and shows high functional group tolerance and broad substrate scope. Radical clock experiments and density functional theory calculations provide insights into the mechanism and rate constants for C‐radical borylation with B 2 cat 2 are disclosed.