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Sequences of Sequences: Spatial Organization of Coded Matter through Layer‐by‐Layer Assembly of Digital Polymers
Author(s) -
Szweda Roza,
Tschopp Michel,
Felix Olivier,
Decher Gero,
Lutz JeanFrançois
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810559
Subject(s) - polyelectrolyte , polymer , layer by layer , monomer , layer (electronics) , sequence (biology) , materials science , phosphoramidite , nanotechnology , chemistry , oligonucleotide , composite material , biochemistry , dna
Abstract A library of 16 digitally encoded polyanions was used in a layer‐by‐layer (LbL) polyelectrolyte assembly to nanofabricate thin films containing digitally coded strata. The polyanions were digital polyphosphodiesters (d‐PPDE) prepared via an automated phosphoramidite process. Each component of the library contained 10 bytes of ASCII‐encoded text (i.e. 80 coded monomers); thus the entire library allows the writing of a full sentence, which can be stored in a multilayer film as a sequence of sequences. To prepare fully segregated digital domains, non‐coded layers composed of poly(allylamine hydrochloride) (PAH)/poly(sodium 4‐styrenesulfonate) (PSS) were included between the d‐PPDE coded layers as an intermediate barrier. Detailed analysis of the film homogeneity indicated formation of 70 nm‐thick films in which digital layers are kept apart from another by non‐coded interlayers. As a result, the sequence‐coded polymer library could be piled‐up in a defined sequence of layers.