Premium
Iron‐Catalyzed Carbenoid‐Transfer Reactions of Vinyl Sulfoxonium Ylides: An Experimental and Computational Study
Author(s) -
Vaitla Janakiram,
Bayer Annette,
Hopmann Kathrin H.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810451
Subject(s) - carbenoid , catalysis , chemistry , substrate (aquarium) , scope (computer science) , computational chemistry , combinatorial chemistry , organic chemistry , rhodium , computer science , geology , oceanography , programming language
A method for the generation of unprecedented vinyl carbenoids from sulfoxonium ylides has been developed and applied in the synthesis of a diverse array of heterocycles such as indolizines, pyrroles, 3‐pyrrolin‐2‐ones, and furans. The reactions proceed by FeBr 2 catalysis under mild reaction conditions with a broad substrate scope. A reaction pathway involving iron carbenoids is proposed based on a series of control experiments and DFT calculations.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom