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N‐Heterocyclic Carbene Catalyzed Quadruple Domino Reactions: Asymmetric Synthesis of Cyclopenta[ c ]chromenones
Author(s) -
Liu Qiang,
Chen XiangYu,
Puttreddy Rakesh,
Rissanen Kari,
Enders Dieter
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810402
Subject(s) - enantioselective synthesis , carbene , domino , chemistry , cyclopentanes , catalysis , cascade reaction , combinatorial chemistry , coumarin , organocatalysis , stereochemistry , organic chemistry
An N‐heterocyclic carbene catalyzed domino sequence via α,β‐unsaturated acyl azolium intermediates has been developed. This strategy provides a convenient enantioselective route to functionalized tricyclic coumarin derivatives and cyclopentanes. DFT studies and control experiments were performed to gain better insight into the reaction mechanism.