Gold(III)‐Catalyzed Site‐Selective and Divergent Synthesis of 2‐Aminopyrroles and Quinoline‐Based Polyazaheterocycles

A facile, site‐selective, and divergent approach to construct 2‐aminopyrroles and quinoline‐fused polyazaheterocycles enabled by a simple gold(III) catalyst from ynamides and anthranils under mild reaction conditions is described. This one‐pot strategy uses readily available starting materials, proceeds in a highly step‐ and atom‐economical manner, with broad substrate scope and scale‐up potential. The key element for success in this tandem reaction is a catalyst‐directed preferred quenching of the in situ generated gold carbene intermediates by a nucleophilic benzyl/2‐furylmethyl moiety on the ynamides as an alternative to the known C−H annulation leading to indoles.