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Aerobic Baeyer–Villiger Oxidation Catalyzed by a Flavin‐Containing Enzyme Mimic in Water
Author(s) -
Chevalier Yoan,
Lock Toy Ki Yvette,
le Nouen Didier,
Mahy JeanPierre,
Goddard JeanPhilippe,
Avenier Frédéric
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201810124
Subject(s) - flavin group , chemistry , catalysis , molecular oxygen , cofactor , aqueous solution , environmentally friendly , flavin adenine dinucleotide , aqueous medium , combinatorial chemistry , enzyme , molecule , photochemistry , artificial enzyme , organic chemistry , ecology , biology
Direct incorporation of molecular oxygen into small organic molecules has attracted much attention for the development of new environmentally friendly oxidation processes. In line with this approach, bioinspired systems mimicking enzyme activities are of particular interest since they may perform catalysis in aqueous media. Demonstrated herein is the incorporation of a natural flavin cofactor (FMN) into the specific microenvironment of a water‐soluble polymer which allows the efficient reduction of the FMN by NADH in aqueous solution. Once reduced, this artificial flavoenzyme can then activate molecular dioxygen under aerobic conditions and result in the Baeyer–Villiger reaction at room temperature in water.