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Amide Effects in C−H Activation: Noncovalent Interactions with L‐Shaped Ligand for meta Borylation of Aromatic Amides
Author(s) -
Bisht Ranjana,
Hoque Md Emdadul,
Chattopadhyay Buddhadeb
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201809929
Subject(s) - borylation , chemistry , amide , bifunctional , ligand (biochemistry) , non covalent interactions , selectivity , stereochemistry , combinatorial chemistry , organic chemistry , molecule , aryl , hydrogen bond , receptor , catalysis , biochemistry , alkyl
A new concept for the meta ‐selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L‐shaped bifunctional ligand has been employed and engages in an O⋅⋅⋅K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C−H activation/borylation.