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Self‐Assembled Aptamer‐Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery
Author(s) -
Yang Lu,
Sun Hao,
Liu Yuan,
Hou Weijia,
Yang Yu,
Cai Ren,
Cui Cheng,
Zhang Penghui,
Pan Xiaoshu,
Li Xiaowei,
Li Long,
Sumerlin Brent S.,
Tan Weihong
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201809753
Subject(s) - nanocarriers , aptamer , drug delivery , biocompatibility , chemistry , nanotechnology , nile red , internalization , targeted drug delivery , nanoparticle , cytotoxicity , dendrimer , biophysics , combinatorial chemistry , materials science , in vitro , organic chemistry , cell , fluorescence , biochemistry , physics , quantum mechanics , biology , genetics
Photoresponsive materials are emerging as ideal carriers for precisely controlled drug delivery owing to their high spatiotemporal selectivity. However, drawbacks such as slow release kinetics, inherent toxicity, and lack of targeting ability hinder their translation into clinical use. We constructed a new DNA aptamer‐grafted photoresponsive hyperbranched polymer, which can self‐assemble into nanoparticles, thereby achieving biocompatibility and target specificity, as well as light‐controllable release behavior. Upon UV‐irradiation, rapid release induced by disassembly was observed for Nile Red‐loaded nanoparticles. Further in vitro cell studies confirmed this delivery system's specific binding and internalization performance arising from the DNA aptamer corona. The DOX‐loaded nanoassembly exhibited selective phototriggered cytotoxicity towards cancer cells, indicating its promising therapeutic effect as a smart drug delivery system.