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Calcium(II)‐Catalyzed Intermolecular Hydroarylation of Deactivated Styrenes in Hexafluoroisopropanol
Author(s) -
Qi Chenxiao,
Gandon Vincent,
Lebœuf David
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201809470
Subject(s) - intermolecular force , chemistry , catalysis , salt (chemistry) , calcium , deuterium , calcium compounds , combinatorial chemistry , organic chemistry , molecule , physics , quantum mechanics
A challenging catalytic hydroarylation of highly electron deficient styrenes has been developed on the basis of efficient cooperation between a calcium(II) triflimide salt and hexafluoroisopropanol (HFIP). This method affords a large variety of diaryl alkanes, notably diaryl ethanes, in good to excellent yields, and is simple to implement and compatible with various functional groups. Furthermore, DFT calculations and deuterium labeling experiments were conducted to elucidate the function of this promoter system.