Solid‐Phase Conversion of Four Stereoisomers into a Single Enantiomer | Zendy

Engwerda Anthonius H. J. | Zendy; Mertens Johannes C. J. | Zendy; Tinnemans Paul | Zendy; Meekes Hugo | Zendy; Rutjes Floris P. J. T. | Zendy; Vlieg Elias | Zendy

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Solid‐Phase Conversion of Four Stereoisomers into a Single Enantiomer

Author(s) -

Engwerda Anthonius H. J.,

Mertens Johannes C. J.,

Tinnemans Paul,

Meekes Hugo,

Rutjes Floris P. J. T.,

Vlieg Elias

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201808913

Subject(s) - stereocenter , enantiomer , phase (matter) , chemistry , combinatorial chemistry , molecule , stereoisomerism , stereochemistry , organic chemistry , enantioselective synthesis , catalysis

Viedma ripening is an emerging method for the solid‐phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor‐made chiral additives, the conversion time can be reduced by a factor of 100.

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