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Solid‐Phase Conversion of Four Stereoisomers into a Single Enantiomer
Author(s) -
Engwerda Anthonius H. J.,
Mertens Johannes C. J.,
Tinnemans Paul,
Meekes Hugo,
Rutjes Floris P. J. T.,
Vlieg Elias
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201808913
Subject(s) - stereocenter , enantiomer , phase (matter) , chemistry , combinatorial chemistry , molecule , stereoisomerism , stereochemistry , organic chemistry , enantioselective synthesis , catalysis
Viedma ripening is an emerging method for the solid‐phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor‐made chiral additives, the conversion time can be reduced by a factor of 100.