Premium
Development of an Alkyne Analogue of the de Mayo Reaction: Synthesis of Medium‐Sized Carbacycles and Cyclohepta[ b ]indoles
Author(s) -
Tymann David,
Tymann Dina Christina,
Bednarzick Ulf,
IovkovaBerends Ljuba,
Rehbein Julia,
Hiersemann Martin
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201808578
Subject(s) - alkyne , intramolecular force , chemistry , ring (chemistry) , stereochemistry , combinatorial chemistry , cascade , organic chemistry , catalysis , chromatography
Embedded medium‐sized carbacycles and cyclohepta[b]indoles occur frequently as scaffold elements in natural products and bioactive compounds. Described herein is a conceptionally novel photochemically triggered cascade process to these scaffolds. Key to the cascading ring‐expansion process is an unprecedented intramolecular alkyne analogue of the de Mayo reaction.