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trans ‐Cyclooctenes as Halolactonization Catalysts
Author(s) -
Einaru Shunsuke,
Shitamichi Kenta,
Nagano Tagui,
Matsumoto Akira,
Asano Keisuke,
Matsubara Seijiro
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201808320
Subject(s) - cyclooctene , catalysis , chemistry , combinatorial chemistry , organic chemistry
The strained olefins in trans ‐cyclooctenes serve as efficient catalysts for halolactonizations, including bromolactonizations and iodolactonizations. The trans ‐cyclooctene framework is essential for excellent catalytic performance, and the substituents also play important roles in determining efficiency. These results are the first demonstration of catalysis by a trans ‐cyclooctene.