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Near‐Infrared Semiconducting Polymer Brush and pH/GSH‐Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor‐Specific Phototheranostics
Author(s) -
Yang Zhen,
Fan Wenpei,
Tang Wei,
Shen Zheyu,
Dai Yunlu,
Song Jibin,
Wang Zhantong,
Liu Yuan,
Lin Lisen,
Shan Lingling,
Liu Yijing,
Jacobson Orit,
Rong Pengfei,
Wang Wei,
Chen Xiaoyuan
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201808074
Tumor‐specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)‐responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self‐assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)‐responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor‐specific phototheranostics with minimal side effects.