α‐Sila‐Dipeptides: Synthesis and Characterization | Zendy

Minkovich Boris | Zendy; Ruderfer Ilya | Zendy; Kaushansky Alexander | Zendy; BravoZhivotovskii Dmitry | Zendy; Apeloig Yitzhak | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

α‐Sila‐Dipeptides: Synthesis and Characterization

Author(s) -

Minkovich Boris,

Ruderfer Ilya,

Kaushansky Alexander,

BravoZhivotovskii Dmitry,

Apeloig Yitzhak

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201807027

Subject(s) - dipeptide , peptide , chemistry , amino acid , molecule , stereochemistry , characterization (materials science) , silicon , combinatorial chemistry , organic chemistry , nanotechnology , materials science , biochemistry

The first two α‐sila‐dipeptides, 7 and cyclo‐sila‐dipeptide 8 , were synthesized and characterized by several methods, including X‐ray crystallography. Bulky t ‐BuMe 2 Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α‐position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research