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Regiospecific N‐Arylation of Aliphatic Amines under Mild and Metal‐Free Reaction Conditions
Author(s) -
Purkait Nibadita,
Kervefors Gabriella,
Linde Erika,
Olofsson Berit
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201807001
Subject(s) - amine gas treating , reagent , chemistry , aryl , alkyl , primary (astronomy) , substrate (aquarium) , combinatorial chemistry , transition metal , organic chemistry , scope (computer science) , catalysis , physics , oceanography , astronomy , geology , computer science , programming language
A transition metal‐free N‐arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N‐alkyl anilines. The methodology is unprecedented among metal‐free methods in terms of amine scope, the ability to transfer both electron‐withdrawing and electron‐donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required.