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NHC‐Catalyzed Electrophilic Trifluoromethylation: Efficient Synthesis of γ‐Trifluoromethyl α,β‐Unsaturated Esters
Author(s) -
Yang Wen,
Ma Dengke,
Zhou Yu,
Dong Xiuqin,
Lin Zhenyang,
Sun Jianwei
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201806674
Subject(s) - trifluoromethylation , regioselectivity , electrophile , chemistry , carbene , catalysis , trifluoromethyl , combinatorial chemistry , reaction mechanism , organic chemistry , alkyl
Described herein is a highly regioselective and efficient N‐heterocyclic‐carbene‐catalyzed γ‐trifluoromethylation of vinylogous enolates. Control experiments and DFT calculations provided important insight into the reaction mechanism.