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The Synthesis of Quinazolinones from Olefins, CO, and Amines over a Heterogeneous Ru‐clusters/Ceria Catalyst
Author(s) -
An Jinghua,
Wang Yehong,
Zhang Zhixin,
Zhao Zhitong,
Zhang Jian,
Wang Feng
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201806266
Subject(s) - quinazolinone , catalysis , chemistry , combinatorial chemistry , environmentally friendly , organic chemistry , heterogeneous catalysis , ecology , biology
Quinazolinones, an important class of heterocyclic compounds, have been widely used in pharmaceuticals because of their biological activity. However, the efficient and economical synthesis of quinazolinones has remained a challenge. A novel synthetic approach has now been developed to produce quinazolinones from olefins, CO, and amines over heterogeneous Ru‐clusters/ceria catalyst in the absence of acids, bases, and oxidants. Furthermore, H 2 O is generated as the only by‐product. A series of quinazolinones with aromatic or non‐aromatic substituents can be obtained in yields of up to 99 %. The Ru‐clusters/ceria can be reused at least four times. The analysis of the E‐factor (environmental impact factor) for the synthesis of 2‐ethyl quinazolinone suggests that this system is more environmentally friendly than other processes reported previously.