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Tailored Cobalt‐Catalysts for Reductive Alkylation of Anilines with Carboxylic Acids under Mild Conditions
Author(s) -
Liu Weiping,
Sahoo Basudev,
Spannenberg Anke,
Junge Kathrin,
Beller Matthias
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201806132
Subject(s) - cobalt , chemistry , alkylation , catalysis , triphos , tetrafluoroborate , organic chemistry , substrate (aquarium) , carboxylic acid , functional group , combinatorial chemistry , ionic liquid , oceanography , polymer , geology
The first cobalt‐catalyzed hydrogenative N ‐methylation and alkylation of amines with readily available carboxylic acid feedstocks as alkylating agents and H 2 as ideal reductant is described. Combination of tailor‐made triphos ligands with cobalt(II) tetrafluoroborate significantly improved the efficiency, thus promoting the reaction under milder conditions. This novel protocol allows for a broad substrate scope with good functional group tolerance, even in the presence of reducible alkenes, esters, and amides.