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Enzyme‐Compatible Dynamic Nanoreactors from Electrostatically Bridged Like‐Charged Surfactants and Polyelectrolytes
Author(s) -
Thiele Martin J.,
Davari Mehdi D.,
Hofmann Isabell,
König Melanie,
Lopez Carlos G.,
Vojcic Ljubica,
Richtering Walter,
Schwaneberg Ulrich,
Tsarkova Larisa A.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201805021
Subject(s) - nanoreactor , dynamic light scattering , polyelectrolyte , chemistry , polyacrylic acid , polymer , micelle , amphiphile , dissipative particle dynamics , pulmonary surfactant , chemical engineering , polymer chemistry , nanotechnology , materials science , organic chemistry , copolymer , nanoparticle , aqueous solution , biochemistry , engineering , catalysis
Abstract Reported is an unanticipated mechanism of attractive electrostatic interactions of fully neutralized polyacrylic acid (PAA) with like‐charged surfactants. Amphiphilic polymer‐surfactant complexes with high interfacial activity and a solubilization capacity exceeding that of conventional micelles are formed by bridging with Ca 2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance because of the improved solubilization of poorly water‐soluble immobilized proteins. Competitive interfacial and intermolecular interactions on different time‐ and length‐scales have been resolved using colorimetric analysis, dynamic tensiometry, light scattering, and molecular dynamic simulations. The discovered bridging association mechanism suggests reengineering of surfactant/polymer/enzyme formulations of modern detergents and opens new opportunities in advancing labile delivery systems.