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Catalytic Alkyne Arylation Using Traceless Directing Groups
Author(s) -
Park JungWoo,
Kang Bubwoong,
Dong Vy M.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804955
Subject(s) - alkyne , chemistry , catalysis , hydrolysis , combinatorial chemistry , component (thermodynamics) , organic chemistry , physics , thermodynamics
Abstract By using Pd 0 /Mandyphos, we achieved a three‐component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α‐arylphenones or α,α‐diarylketones. This Pd‐catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C−C bond formation.