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Selection of Anti‐gluten DNA Aptamers in a Deep Eutectic Solvent
Author(s) -
Svigelj Rossella,
Dossi Nicolò,
Toniolo Rosanna,
MirandaCastro Rebeca,
delosSantosÁlvarez Noemí,
LoboCastañón M. Jesús
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804860
Subject(s) - aptamer , eutectic system , gluten , deep eutectic solvent , dna , selection (genetic algorithm) , chemistry , nanotechnology , combinatorial chemistry , materials science , computer science , biology , biochemistry , microbiology and biotechnology , artificial intelligence , organic chemistry , alloy
Herein, we show the feasibility of using deep eutectic solvents as a faster way of selecting aptamers targeting poorly water‐soluble species. This unexplored concept is illustrated for gluten proteins. In this way, aptamer‐based gluten detection can be performed directly in the extraction media with improved detectability. We envision deep implications for applications not only in food safety control but also in biomedicine.