Premium
BODIPY Peptide Labeling by Late‐Stage C(sp 3 )−H Activation
Author(s) -
Wang Wei,
Lorion Mélanie M.,
Martinazzoli Oscar,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804654
Subject(s) - bodipy , racemization , peptide , chemistry , combinatorial chemistry , fluorescence , palladium , stereochemistry , biochemistry , catalysis , physics , quantum mechanics
Late‐stage BODIPY diversification of structurally complex amino acids and peptides was accomplished by racemization‐free palladium‐catalyzed C(sp 3 )−H activation. Transformative fluorescence modification proved viable by triazole‐assisted C(sp 3 )−H arylation in a chemo‐ and site‐selective fashion, providing modular access to novel BODIPY peptide sensors.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom