Premium
BODIPY Peptide Labeling by Late‐Stage C(sp 3 )−H Activation
Author(s) -
Wang Wei,
Lorion Mélanie M.,
Martinazzoli Oscar,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804654
Subject(s) - bodipy , racemization , peptide , chemistry , combinatorial chemistry , fluorescence , palladium , stereochemistry , biochemistry , catalysis , physics , quantum mechanics
Late‐stage BODIPY diversification of structurally complex amino acids and peptides was accomplished by racemization‐free palladium‐catalyzed C(sp 3 )−H activation. Transformative fluorescence modification proved viable by triazole‐assisted C(sp 3 )−H arylation in a chemo‐ and site‐selective fashion, providing modular access to novel BODIPY peptide sensors.