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Chiral Recognition and Separation by Chirality‐Enriched Metal–Organic Frameworks
Author(s) -
Das Saikat,
Xu Shixian,
Ben Teng,
Qiu Shilun
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804383
Subject(s) - chirality (physics) , metal organic framework , enantiomer , dopant , materials science , metal , nanotechnology , membrane , polymer , combinatorial chemistry , chemistry , chemical physics , organic chemistry , doping , chiral symmetry , physics , optoelectronics , adsorption , quantum mechanics , nambu–jona lasinio model , quark , biochemistry
Abstract Endowed with chiral channels and pores, chiral metal–organic frameworks (MOFs) are highly useful; however, their synthesis remains a challenge given that most chiral building blocks are expensive. Although MOFs with induced chirality have been reported to avoid this shortcoming, no study providing evidence for the ee value of such MOFs has yet been reported. We herein describe the first study on the efficiency of chiral induction in MOFs using inexpensive achiral building blocks and fully recoverable chiral dopants to control the handedness of racemic MOFs. This method yielded chirality‐enriched MOFs with accessible pores. The ability of the materials to form host–guest complexes was probed with enantiomers of varying size and coordination and in solvents with varying polarity. Furthermore, mixed‐matrix membranes (MMMs) composed of chirality‐enriched MOF particles dispersed in a polymer matrix demonstrated a new route for chiral separation.