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More Than 12 % Polarization and 20 Minute Lifetime of 15 N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water
Author(s) -
McCormick Jeffrey,
Korchak Sergey,
Mamone Salvatore,
Ertas Yavuz N.,
Liu Zhiyu,
Verlinsky Luke,
Wagner Shawn,
Glöggler Stefan,
Bouchard LouisS.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804185
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , chemistry , polarization (electrochemistry) , catalysis , rhodium , induced polarization , deuterium , hydrogen , stereochemistry , nuclear magnetic resonance spectroscopy , organic chemistry , physics , quantum mechanics , electrical resistivity and conductivity
Hyperpolarization techniques are key to extending the capabilities of MRI for the investigation of structural, functional and metabolic processes in vivo. Recent heterogeneous catalyst development has produced high polarization in water using parahydrogen with biologically relevant contrast agents. A heterogeneous ligand‐stabilized Rh catalyst is introduced that is capable of achieving 15 N polarization of 12.2±2.7 % by hydrogenation of neurine into a choline derivative. This is the highest 15 N polarization of any parahydrogen method in water to date. Notably, this was performed using a deuterated quaternary amine with an exceptionally long spin‐lattice relaxation time ( T 1 ) of 21.0±0.4 min. These results open the door to the possibility of 15 N in vivo imaging using nontoxic similar model systems because of the biocompatibility of the production media and the stability of the heterogeneous catalyst using parahydrogen‐induced polarization (PHIP) as the hyperpolarization method.