Premium
Total Synthesis of (+)‐ and (±)‐Hosieine A
Author(s) -
Huang YuWen,
Kong Ke,
Wood John L.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201804076
Subject(s) - chemistry , ligand (biochemistry) , sequence (biology) , total synthesis , combinatorial chemistry , acetylcholine receptor , stereochemistry , receptor , biochemistry
Described herein is a concise total synthesis of the highly potent nicotinic acetylcholine receptor ligand hosieine A in racemic and enantioenriched forms. The synthesis requires only seven steps and features a telescoped reaction sequence initiated by a gold‐catalyzed Rautenstrauch reaction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom