Divergent Total Syntheses of Enmein‐Type Natural Products: (−)‐Enmein, (−)‐Isodocarpin, and (−)‐Sculponin R | Zendy

Pan Saiyong | Zendy; Chen Sicong | Zendy; Dong Guangbin | Zendy

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Divergent Total Syntheses of Enmein‐Type Natural Products: (−)‐Enmein, (−)‐Isodocarpin, and (−)‐Sculponin R

Author(s) -

Pan Saiyong,

Chen Sicong,

Dong Guangbin

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201803709

Subject(s) - construct (python library) , acylation , chemistry , total synthesis , ring (chemistry) , stereochemistry , natural (archaeology) , combinatorial chemistry , organic chemistry , computer science , biology , catalysis , programming language , paleontology

Divergent total syntheses of the enmein‐type natural products (−)‐enmein, (−)‐isodocarpin, and (−)‐sculponin R have been achieved in a concise fashion. Key features of the strategy include 1) an efficient early‐stage cage formation to control succeeding diastereoselectivity, 2) a one‐pot acylation/akylation/lactonization to construct the C‐ring and C8 quarternary center, 3) a reductive alkenylation approach to construct the enmain D/E rings and 4) a flexible route to allow divergent syntheses of three natural products.

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