CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes | Zendy

Zhou Yujing | Zendy; Engl Oliver D. | Zendy; Bandar Jeffrey S. | Zendy; Chant Emma D. | Zendy; Buchwald Stephen L. | Zendy

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CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes

Author(s) -

Zhou Yujing,

Engl Oliver D.,

Bandar Jeffrey S.,

Chant Emma D.,

Buchwald Stephen L.

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201802797

Subject(s) - enantioselective synthesis , electrophile , reagent , catalysis , chemistry , combinatorial chemistry , transformation (genetics) , reaction conditions , stereochemistry , organic chemistry , biochemistry , gene

A CuH‐catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2‐dioxazol‐5‐ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.

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