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CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes
Author(s) -
Zhou Yujing,
Engl Oliver D.,
Bandar Jeffrey S.,
Chant Emma D.,
Buchwald Stephen L.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201802797
Subject(s) - enantioselective synthesis , electrophile , reagent , catalysis , chemistry , combinatorial chemistry , transformation (genetics) , reaction conditions , stereochemistry , organic chemistry , biochemistry , gene
A CuH‐catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2‐dioxazol‐5‐ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.