Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need for a Strong Oxidant | Zendy

Wang Jin | Zendy; Zhang Shuyao | Zendy; Xu Chang | Zendy; Wojtas Lukasz | Zendy; Akhmedov Novruz G. | Zendy; Chen Hao | Zendy; Shi Xiaodong | Zendy

Premium

Highly Efficient and Stereoselective Thioallylation of Alkynes: Possible Gold Redox Catalysis with No Need for a Strong Oxidant

Author(s) -

Wang Jin,

Zhang Shuyao,

Xu Chang,

Wojtas Lukasz,

Akhmedov Novruz G.,

Chen Hao,

Shi Xiaodong

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201802540

Subject(s) - chemistry , catalysis , sulfonium , redox , alkyne , stereoselectivity , intramolecular force , combinatorial chemistry , substrate (aquarium) , photochemistry , organic chemistry , salt (chemistry) , oceanography , geology

Stereoselective thioallylation of alkynes under possible gold redox catalysis was accomplished with high efficiency (as low as 0.1 % catalyst loading, up to 99 % yield) and broad substrate scope (various alkynes, inter‐ and intramolecular fashion). The gold(I) catalyst acts as both a π‐acid for alkyne activation and a redox catalyst for Au I/III coupling, whereas the sulfonium cation generated in situ functions as a mild oxidant. This novel methodology provides an exciting system for gold redox catalysis without the need for a strong oxidant.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research