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Electrochemical C−H Amination by Cobalt Catalysis in a Renewable Solvent
Author(s) -
Sauermann Nicolas,
Mei Ruhuai,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201802206
Subject(s) - amination , electrocatalyst , cobalt , chemistry , catalysis , electrochemistry , solvent , green chemistry , electrophile , palladium , stoichiometry , combinatorial chemistry , organic chemistry , reaction mechanism , electrode
Syntheses of substituted anilines primarily rely on palladium‐catalyzed coupling chemistry with prefunctionalized aryl electrophiles. While oxidative aminations have emerged as powerful alternatives, they largely produce undesired metal‐containing by‐products in stoichiometric quantities. In contrast, described herein is the unprecedented electrochemical C−H amination by cobalt‐catalyzed C−H activation. The environmentally benign electrocatalysis avoids stoichiometric metal oxidants, can be conducted under ambient air, and employs a biomass‐derived, renewable solvent for sustainable aminations in an atom‐ and step‐economical manner with H 2 as the sole byproduct.