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A Dynamic Chemical Network for Cystinuria Diagnosis
Author(s) -
Lafuente Maria,
Solà Jordi,
Alfonso Ignacio
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201802189
Subject(s) - cystinuria , cystine , cysteine , covalent bond , computer science , chemistry , aqueous medium , fluorescence , nanotechnology , combinatorial chemistry , biochemical engineering , computational biology , aqueous solution , biochemistry , materials science , organic chemistry , biology , engineering , enzyme , physics , quantum mechanics
The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non‐covalent interactions, the design of stimulus‐responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. The binding and sensing units are encoded in the components that dynamically assemble and disassemble responding to external stimuli as a successful tool to detect both cysteine and cystine in aqueous media. Moreover, the dynamic sensing system works in human urine, as a prospective application for cystinuria diagnosis.