Premium
Alkyl Ethers as Traceless Hydride Donors in Brønsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer
Author(s) -
Gandamana Dhika Aditya,
Wang Bin,
Tejo Ciputra,
Bolte Benoit,
Gagosz Fabien,
Chiba Shunsuke
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201801953
Subject(s) - chemistry , intramolecular force , brønsted–lowry acid–base theory , hydride , isopropyl , catalysis , transfer hydrogenation , deoxygenation , alkyl , hydrogen atom , medicinal chemistry , organic chemistry , combinatorial chemistry , hydrogen , ruthenium
A new protocol for the deoxygenation of alcohols and the hydrogenation of alkenes under Brønsted acid catalysis has been developed. The method is based on the use of either a benzyl or isopropyl ether as a traceless hydrogen‐atom donor, and involves an intramolecular hydride transfer as a key step, which is achieved in a regio‐ and stereoselective manner.