Alkyl Ethers as Traceless Hydride Donors in Brønsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer | Zendy

Gandamana Dhika Aditya | Zendy; Wang Bin | Zendy; Tejo Ciputra | Zendy; Bolte Benoit | Zendy; Gagosz Fabien | Zendy; Chiba Shunsuke | Zendy

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Alkyl Ethers as Traceless Hydride Donors in Brønsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer

Author(s) -

Gandamana Dhika Aditya,

Wang Bin,

Tejo Ciputra,

Bolte Benoit,

Gagosz Fabien,

Chiba Shunsuke

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201801953

Subject(s) - chemistry , intramolecular force , brønsted–lowry acid–base theory , hydride , isopropyl , catalysis , transfer hydrogenation , deoxygenation , alkyl , hydrogen atom , medicinal chemistry , organic chemistry , combinatorial chemistry , hydrogen , ruthenium

A new protocol for the deoxygenation of alcohols and the hydrogenation of alkenes under Brønsted acid catalysis has been developed. The method is based on the use of either a benzyl or isopropyl ether as a traceless hydrogen‐atom donor, and involves an intramolecular hydride transfer as a key step, which is achieved in a regio‐ and stereoselective manner.

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