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Brønsted Acid Enabled Nickel‐Catalyzed Hydroalkenylation of Aldehydes with Styrene and its Derivatives
Author(s) -
Han XingWang,
Zhang Tao,
Zheng YanLong,
Yao WeiWei,
Li JiangFei,
Pu YouGe,
Ye Mengchun,
Zhou QiLin
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201801817
Subject(s) - styrene , brønsted–lowry acid–base theory , chemistry , aldehyde , catalysis , alkene , yield (engineering) , nickel , selectivity , allylic rearrangement , organic chemistry , copolymer , materials science , polymer , metallurgy
A Brønsted acid enabled nickel‐catalyzed hydroalkenylation of aldehydes and styrene derivatives has been developed. The Brønsted acid acts as a proton shuttle to transfer a proton from the alkene to the aldehyde, thereby leading to an economical and byproduct‐free coupling. A series of synthetically useful allylic alcohols were obtained through one‐step reactions from readily available styrene derivatives and aliphatic aldehydes in up to 88 % yield and with high linear selectivity.