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Atom‐Economic Silver‐Catalyzed Difunctionalization of the Isocyano Group with Cyclic Oximes: Towards Pyrimidinediones
Author(s) -
Liang HongWen,
Yang Zhen,
Jiang Kun,
Ye Ying,
Wei Ye
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201801363
Subject(s) - combinatorial chemistry , catalysis , chemistry , atom (system on chip) , molecule , group (periodic table) , functional group , organic chemistry , computer science , polymer , embedded system
An unprecedented silver‐catalyzed difunctionalization of the isocyano group with cyclic oximes is described. This method allows efficient and atom‐economic assembly of a vast array of structurally novel and interesting pyrimidinediones, and tolerates a range of functionalities. The resulting products can be easily converted into some useful compounds. Furthermore, the method can also be applied for the late‐stage modification of a few biologically active molecules.