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Enantioselective Denitrogenative Annulation of 1 H ‐Tetrazoles with Styrenes Catalyzed by Rhodium
Author(s) -
Nakamuro Takayuki,
Hagiwara Kohei,
Miura Tomoya,
Murakami Masahiro
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201801283
Subject(s) - rhodium , annulation , carbenoid , enantioselective synthesis , chemistry , catalysis , organic chemistry , medicinal chemistry
Sulfonylation of 1 H ‐tetrazoles with triflic anhydride in the presence of chiral rhodium(II) carboxylate dimers causes denitrogenation to generate α‐azo rhodium(II) carbenoid species as new types of donor/acceptor carbenoids, which then readily react with styrenes to afford 3,5‐diaryl‐2‐pyrazolines with a high degree of enantioselectivity.