Selective C(sp 3 )−H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow | Zendy

Laudadio Gabriele | Zendy; Govaerts Sebastian | Zendy; Wang Ying | Zendy; Ravelli Davide | Zendy; Koolman Hannes F. | Zendy; Fagi Maurizio | Zendy; Djuric Stevan W. | Zendy; Noël Timothy | Zendy

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Selective C(sp 3 )−H Aerobic Oxidation Enabled by Decatungstate Photocatalysis in Flow

Author(s) -

Laudadio Gabriele,

Govaerts Sebastian,

Wang Ying,

Ravelli Davide,

Koolman Hannes F.,

Fagi Maurizio,

Djuric Stevan W.,

Noël Timothy

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201800818

Subject(s) - photocatalysis , chemistry , photochemistry , irradiation , oxygen , catalysis , organic chemistry , physics , nuclear physics

A mild and selective C(sp 3 )−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen and enhanced irradiation of the reaction mixture. Our method allows for the oxidation of both activated and unactivated C−H bonds (30 examples). The ability to selectively oxidize natural scaffolds, such as (−)‐ambroxide, pregnenolone acetate, (+)‐sclareolide, and artemisinin, exemplifies the utility of this new method.

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