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Mechanism‐Based Condition Screening for Sustainable Catalysis in Single‐Electron Steps by Cyclic Voltammetry
Author(s) -
Liedtke Theresa,
Spannring Peter,
Riccardi Ludovico,
Gansäuer Andreas
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201800731
Subject(s) - chemistry , cyclic voltammetry , catalysis , electrolysis , mechanism (biology) , combinatorial chemistry , computational chemistry , electrochemistry , organic chemistry , electrode , physics , electrolyte , quantum mechanics
A cyclic‐voltammetry‐based screening method for Cp 2 TiX‐catalyzed reactions is introduced. Our mechanism‐based approach enables the study of the influence of various additives on the electrochemically generated active catalyst Cp 2 TiX, which is in equilibrium with catalytically inactive [Cp 2 TiX 2 ] − . Thioureas and ureas are most efficient in the generation of Cp 2 TiX in THF. Knowing the precise position of the equilibrium between Cp 2 TiX and [Cp 2 TiX 2 ] − allowed us to identify reaction conditions for the bulk electrolysis of Cp 2 TiX 2 complexes and for Cp 2 TiX‐catayzed radical arylations without having to carry out the reactions. Our time‐ and resource‐efficient approach is of general interest for the design of catalytic reactions that proceed in single‐electron steps.