Premium
KCa(H 2 O) 2 [Fe III (CN) 6 ]⋅H 2 O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus
Author(s) -
Wang Zhongxia,
Yu Bing,
Alamri Huda,
Yarabarla Sriramakrishna,
Kim MinHo,
Huang Songping D.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201713177
Subject(s) - prussian blue , chemistry , nanoparticle , ion exchange , intracellular , nuclear chemistry , staphylococcus aureus , membrane , bacteria , bacterial cell structure , antimicrobial , inorganic chemistry , ion , nanotechnology , biochemistry , materials science , organic chemistry , biology , electrode , electrochemistry , genetics
Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H 2 O) 2 [Fe III (CN) 6 ]⋅H 2 O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.