Optogenetic Control of Voltage‐Gated Calcium Channels | Zendy

Ma Guolin | Zendy; Liu Jindou | Zendy; Ke Yuepeng | Zendy; Liu Xin | Zendy; Li Minyong | Zendy; Wang Fen | Zendy; Han Gang | Zendy; Huang Yun | Zendy; Wang Youjun | Zendy; Zhou Yubin | Zendy

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Optogenetic Control of Voltage‐Gated Calcium Channels

Author(s) -

Ma Guolin,

Liu Jindou,

Ke Yuepeng,

Liu Xin,

Li Minyong,

Wang Fen,

Han Gang,

Huang Yun,

Wang Youjun,

Zhou Yubin

Publication year - 2018

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201713080

Subject(s) - optogenetics , depolarization , chemistry , biophysics , voltage dependent calcium channel , gtpase , calcium signaling , calcium , microbiology and biotechnology , neuroscience , biology , biochemistry , organic chemistry

Voltage‐gated Ca 2+ (Ca V ) channels mediate Ca 2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca V channel modulators, to enable photo‐tunable modulation of Ca V channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for Ca V channels could find broad applications in interrogating a wide range of Ca V ‐mediated physiological processes.

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