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Avoiding Thiol Compound Interference: A Nanoplatform Based on High‐Fidelity Au–Se Bonds for Biological Applications
Author(s) -
Hu Bo,
Kong Fanpeng,
Gao Xiaonan,
Jiang Lulu,
Li Xiaofeng,
Gao Wen,
Xu Kehua,
Tang Bo
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201712921
Subject(s) - covalent bond , biomolecule , thiol , chemistry , nanomaterials , combinatorial chemistry , nanoparticle , selectivity , nanotechnology , colloidal gold , materials science , organic chemistry , catalysis
Gold nanoparticles (Au NPs) assembled through Au−S covalent bonds have been widely used in biomolecule‐sensing technologies. However, during the process, detection distortions caused by high levels of thiol compounds can still significantly influence the result and this problem has not really been solved. Based on the higher stability of Au−Se bonds compared to Au−S bonds, we prepared selenol‐modified Au NPs as an Au‐Se nanoplatform (NPF). Compared with the Au‐S NPF, the Au‐Se NPF exhibits excellent anti‐interference properties in the presence of millimolar levels of glutathione (GSH). Such an Au‐Se NPF that can effectively avoid detection distortions caused by high levels of thiols thus offers a new perspective in future nanomaterial design, as well as a novel platform with higher stability and selectivity for the in vivo application of chemical sensing and clinical therapies.