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Radical Alkyne peri ‐Annulation Reactions for the Synthesis of Functionalized Phenalenes, Benzanthrenes, and Olympicene
Author(s) -
Tsvetkov Nikolay P.,
GonzalezRodriguez Edgar,
Hughes Audrey,
dos Passos Gomes Gabriel,
White Frankie D.,
Kuriakose Febin,
Alabugin Igor V.
Publication year - 2018
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201712783
Subject(s) - electrophile , chemistry , annulation , alkyne , combinatorial chemistry , peri , substrate (aquarium) , radical cyclization , organic chemistry , catalysis , philosophy , oceanography , theology , geology
Radical cyclization reactions at a peri position were used for the synthesis of polyaromatic compounds. Depending on the choice of reaction conditions and substrate, this flexible approach led to Bu 3 Sn‐substituted phenalene, benzanthrene, and olympicene derivatives. Subsequent reactions with electrophiles provided synthetic access to previously inaccessible functionalized polyaromatic compounds.